Beekeepers show way to allergen tolerance

local autoreactive T cells that had previously ignored epithelial self-antigens. IFNand RbAp48 were also found in epithelial cells of patients with Sjögren’s syndrome. Professional APCs seem to be required to start or maintain autoimmunity when estrogen levels are normal, as transferring T cells from transgenic lymph nodes into nontransgenic mice initiated gland cell destruction only if APCs were included. But epithelial cells may be selfsufficient APCs in the absence of estrogen; T cells from the transgenic mice were enough to cause disease in mice whose ovaries had been removed. NL